Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 11, Issue 11, Pages 1859-1898Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2015.2145
Keywords
Cancer; Multi-Drug Resistance; Combination Chemotherapy; Nanoparticles; Drug Delivery; Targeted Nanoparticles; Multifunctional Nanoparticles
Funding
- National Institute of General Medical Science of the National Institutes of Health [SC3GM109873]
- Hawai'i Community Foundation, Honolulu, HI, USA
- Research Corporation of the University of Hawai'i at Hilo, Hilo, HI, USA
- Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI, USA
- Kamehameha Schools, Honolulu, HI, USA
- Liko A'e Foundation, Kahului, HI, USA
- Ke Ola Mau program, Hilo, HI, USA
- University of Hawai'i Foundation, Honolulu, HI, USA
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Nanotechnology and combination therapy are two major fields that show great promise in the treatment of cancer. The delivery of drugs via nanoparticles helps to improve drug's therapeutic effectiveness while reducing adverse side effects associated with high dosage by improving their pharmacokinetics. Taking advantage of molecular markers over-expressing on tumor tissues compared to normal cells, an active molecular marker targeted approach would be-beneficial for cancer therapy. These actively targeted nanoparticles would increase drug concentration at the tumor site, improving efficacy while further reducing chemo-resistance. The multidisciplinary approach may help to improve the overall efficacy in cancer therapy. This review article summarizes recent developments of targeted multifunctional nanoparticles in the delivery of various drugs for a combinational chemotherapy approach to cancer treatment and imaging.
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