Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1800, Issue 10, Pages 1106-1112Publisher
ELSEVIER
DOI: 10.1016/j.bbagen.2009.10.002
Keywords
Astroglia; Estradiol; Microglia; Myelin; Oligodendroglia; Selective estrogen receptor modulator
Categories
Funding
- Spanish Ministerio de Ciencia e Innovacion [BFU 2008-02950-C03-01, BFU 2008-02950-C03-02]
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Glial cells are directly or indirectly affected by estradiol and by different estrogenic compounds, such as selective estrogen receptor modulators. Acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after brain injury. In addition, estradiol induces the expression and release of growth factors by glial cells that promote neuronal survival. Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds. (C) 2009 Elsevier B.V. All rights reserved.
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