Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1790, Issue 5, Pages 283-308Publisher
ELSEVIER
DOI: 10.1016/j.bbagen.2009.03.011
Keywords
Drug; Marine; Metabolite; Natural product; Pharmacology; Review; Toxicology
Categories
Funding
- NIAID NIH HHS [R01 AI036596, R01 AI036596-12] Funding Source: Medline
- NIGMS NIH HHS [S06GM08102, SC1 GM086271, S06 GM008102] Funding Source: Medline
- PHS HHS [1R01A136596] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI036596] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [SC1GM086271, S06GM008102] Funding Source: NIH RePORTER
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Background: The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented. Results: Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. Conclusions: Marine pharmacology research during 2005-2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents. General significance: Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity will probably result in novel therapeutic agents for the treatment of multiple disease categories. (C) 2009 Elsevier B.V. All rights reserved.
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