Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 54, Issue 3, Pages 191-195Publisher
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/jcp.54.3.191
Keywords
severe combined immunodeficiency; bone marrow transplantation; adenosine deaminase deficiency
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Early diagnosis of severe combined immunodeficiency (SCID) is important to enable prompt referral to a supraregional centre for bone marrow transplantation before the occurrence of end organ damage secondary to infective complications. This review outlines clinical, microbiological, and immunopathological clues that aid the diagnosis of SCID and emphasises the multidisciplinary approach needed to diagnose and treat these infants.
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