Journal
FARMACO
Volume 56, Issue 3, Pages 233-237Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(01)01037-0
Keywords
6-substituted-3-pyridazinone derivatives; antinociceptive activity; Koster test
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A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.
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