Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1780, Issue 3, Pages 410-420Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2007.08.009
Keywords
glycosylphosphatidylinositol; GPI-anchored proteins; lipid remodeling; microdomain; lipid rafts
Categories
Ask authors/readers for more resources
Many proteins are attached to the cell surface via a conserved post-stranslational modification, the glycosylphospbatidylinositol (GPI) anchor. GPI-anchored proteins are tunctionally diverse, but one of their most striking features is their association with lipid microdomains, which consist mainly of sphingolipids and sterols. GPI-anchored proteins modulate various biological functions when they are incorporated into these specialized domains. The biosynthesis of GPI and its attachment to proteins occurs in the endoplasmic reticulum. The lipid moieties of GPI-anchored proteins are further modified during their transport to the cell surface, and these remodeling processes are essential for the association of proteins with lipid microdomains. Recently, several genes required for GPI lipid remodeling have been identified in yeast and mammalian cells. In this review, we describe the pathways for lipid remodeling of GPI-anchored proteins in yeast and mammalian cells, and discuss how lipid remodeling affects the association of GPI-anchored proteins with microdomains in cellular events. (c) 2007 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available