Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1780, Issue 11, Pages 1318-1324Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2008.03.007
Keywords
nitric oxide; redox biology; oxidants; lipid oxidation; nitration; free redicals
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Funding
- FOGARTY-NIH
- The Wellcome Trust (UK)
- Fondo Clemente Estable
- Programa de Desarrollo Tecnologico
- DINACYT (Uruguay)
- Howard Hughes Medical Institute (USA)
- International Centre of Genetic Engineering and Biotechnology (Italy)
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Protein and lipid nitration represent novel footprints of oxidative and nitrative stress processes. In this review, we first discuss the mechanisms of formation of protein 3-nitrotyrosine and nitrated fatty acids as well as their key biological and signaling actions. Elevation of protein 3-nitrotyrosine levels is associated to tissue injury, and some specific nitrated proteins play a causative role in disease progression; on the other hand, the substantiation on the role of tyrosine nitration on redox signaling is rather scarce. Herein, we also provide evidence to support that the nitration of lipids (i.e. to nitrofatty acids) results in the formation of novel endogenous modulators of redox processes, partially counteracting pro-inflammatory effects of oxidant exposure. (C) 2008 Elsevier B.V. All rights reserved.
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