Journal
JOURNAL OF IMMUNOLOGY
Volume 166, Issue 5, Pages 2917-2921Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.5.2917
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Funding
- NIAID NIH HHS [AI41510] Funding Source: Medline
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Fas:Fas ligand pathway is critical in regulating immune homeostasis by eliminating activated T cells that proliferated in response to an infection. Here, ne show that the MHC class II transactivator (CIITA) can suppress this pathway by inhibiting transcription of the Fas ligand gene. CIITA can effectively repress transcription from the Fas ligand promoter in both T cell lines as well as primary cells. The repression appears to be at least partly due to interference of NFAT-mediated induction of Fos ligand gene transcription. T cells that express CIITA constitutively do not up-regulate Fas ligand on the cell surface after activation ria the TCR. Consequently, these cells lack the ability to undergo activation-induced cell death, and to kill Fas-bearing target cells.
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