Journal
JOURNAL OF PEDIATRICS
Volume 138, Issue 3, Pages 428-431Publisher
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2001.111273
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Nineteen of 35 children (54%) with acute lymphoblastic leukemia receiving maintenance therapy consisting of daily oral 6-mercaptopurine and weekly Oral methotrexate developed hypoglycemia (blood glucose level <2.7 mmol/L [50 mg/dL] or <2.9 mmol/L [54 mg/dL] with symptoms) during 16 hours of overnight fasting. In 15 of 15 re-studied children, fasting tolerance had improved, and in 67% (10/15), it had become normal a few months after cessation of therapy.
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