Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1839, Issue 10, Pages 931-938Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2014.05.013
Keywords
SAM; S-adenosyl-L-methionine; Riboswitch; Regulatory RNA; Antitermination; Ribosome binding site
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Funding
- NIH [GM-086766]
- CIHR
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The recent discovery of short cis-acting RNA elements termed riboswitches has caused a paradigm shift in our understanding of genetic regulatory mechanisms. The three distinct superfamilies of S-adenosyl-L-methionine (SAM) riboswitches are the most commonly found riboswitch classes in nature. These RNAs represent three independent evolutionary solutions to achieve specific SAM recognition. This review summarizes research on 1) modes of gene regulatory mechanisms, 2) common themes and differences in ligand recognition, and 3) ligand-induced conformational dynamics among SAM riboswitch families. The body of work on the SAM riboswitch families constitutes a useful primer to the topic of gene regulatory RNAs as a whole. This article is part of a Special Issue entitled: Riboswitches. (c) 2014 Elsevier B.V. All rights reserved.
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