Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1839, Issue 3, Pages 215-222Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2013.10.009
Keywords
Noncoding RNA; Epigenetics; IncRNA; Polycomb
Categories
Funding
- MEXT, Japan
- Grants-in-Aid for Scientific Research [21115007, 26113006, 23370093, 21228003] Funding Source: KAKEN
Ask authors/readers for more resources
Systematic transcriptome analysis has revealed that a vast majority of the mammalian genome is transcribed into RNA, thus establishing the concept of pervasive transcription. More than half of these RNAs do not encode proteins, and they are collectively called noncoding RNAs. Although the physiological relevance of the transcription of these noncoding RNAs has remained unclear, it was recently proposed that one of the major roles of long noncoding RNAs (IncRNAs) in the nucleus is the regulation of gene expression at the transcriptional level via histone or DNA modification. In this review, we will summarize the advancement of our understanding of the molecular mechanisms of IncRNAs. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available