Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1839, Issue 12, Pages 1433-1439Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2014.03.009
Keywords
Post-translational modifications; Histones; Heterochromatin; Epigenetics; Chromatin assembly; Genomic integrity
Categories
Funding
- CONICYT fellowship [22121806]
- la Ligue Nationale contre le Cancer (Equipe labellisee Ligue and postdoctoral fellowship)
- European Commission Network of Excellence EpiGeneSys [HEALTH-F4-2010-257082]
- ERC [2009-AdG_20090506]
- European Commission [FP7_HEALTH-2010-259743]
- ANR [ANR-10-BLAN-1326-03, ANR-11-LABX-0044_DEEP, ANR-10-IDEX-0001-02 PSL, ANR-12-BSV5-0022-02]
- Aviesan-ITMO cancer project Epigenomics of breast cancer
- ANILLO [ACT1119]
- Basal Project [PFB16]
- FONDECYT [1120170]
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In eukaryotic organisms, the replication of the DNA sequence and its organization into chromatin are critical to maintain genome integrity. Chromatin components, such as histone variants and histone post-translational modifications, along with the higher-order chromatin structure, impact several DNA metabolic processes, including replication, transcription, and repair. In this review we focus on lysine methylation and the relationships between this histone mark and chromatin replication. We first describe studies implicating lysine methylation in regulating early steps in the replication process. We then discuss chromatin reassembly following replication fork passage, where the incorporation of a combination of newly synthesized histones and parental histones can impact the inheritance of lysine methylation marks on the daughter strands. Finally, we elaborate on how the inheritance of lysine methylation can impact maintenance of the chromatin landscape, using heterochromatin as a model chromatin domain, and we discuss the potential mechanisms involved in this process. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond. (C) 2014 Elsevier B.V. All rights reserved.
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