Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1839, Issue 10, Pages 964-973Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2014.05.005
Keywords
Synthetic biology; Engineered riboswitch; Aptamer; Theophylline; Tetracycline; Ribozyme
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB902-A2]
- LOEWE CGT [HMWK III L 4- 518/17.004]
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Within the last decade, it has become obvious that RNA plays an important role in regulating gene expression. This has led to a plethora of approaches aiming at exploiting the outstanding chemical properties of RNA to develop synthetic RNA regulators for conditional gene expression systems. Consequently, many different regulators have been developed to act on various stages of gene expression. They can be engineered to respond to almost any ligand of choice and are, therefore, of great interest for applications in synthetic biology. This review presents an overview of such engineered riboswitches, discusses their applicability and points out recent trends in their development. This article is part of a Special Issue entitled: Riboswitches. (c) 2014 Elsevier B.V. All rights reserved.
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