Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1829, Issue 8, Pages 775-790Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2013.01.007
Keywords
Ribosome assembly; ATP-dependent RNA helicase; Nucleolus; Pre-rRNA processing; snoRNA; Pre-rRNA rearrangement
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Funding
- Spanish Ministry of Science and Innovation (MICINN)
- ERDF [BFU2010-15690]
- Andalusian Government [BIO-271, P08-CVI-03508]
- MICINN
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Ribosome biogenesis is a fundamental process that is conserved in eukaryotes. Although spectacular progress has been made in understanding mammalian ribosome synthesis in recent years, by far, this process has still been best characterised in the yeast Saccharomyces cerevisiae. In yeast, besides the rRNAs, the ribosomal proteins and the 75 small nudeolar RNAs, more than 250 non-ribosomal proteins, generally referred to as trans-acting factors, are involved in ribosome biogenesis. These factors include nucleases, RNA modifying enzymes, ATPases, GTPases, kinases and RNA helicases. Altogether, they likely confer speed, accuracy and directionality to the ribosome synthesis process, however, the precise functions for most of them are still largely unknown. This review summarises our current knowledge on eukaryotic RNA helicases involved in ribosome biogenesis, particularly focusing on the most recent advances with respect to the molecular roles of these enzymes and their co-factors in yeast and human cells. This article is part of a Special Issue entitled: The Biology of RNA helicases-Modulation for life. (C) 2013 Elsevier B.V. All rights reserved.
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