Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1829, Issue 1, Pages 169-173Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2012.08.004
Keywords
Transcription; Translation; mRNA decay
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Funding
- Israel Science Foundation
- US-Israel Binational Science Foundation
- Rappaport Foundation
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In eukaryotes, nuclear mRNA synthesis is physically separated from its cytoplasmic translation and degradation. Recent unexpected findings have revealed that, despite this separation, the transcriptional machinery can remotely control the cytoplasmic stages. Key to this coupling is the capacity of the transcriptional machinery to imprint the transcript with factors that escort it to the cytoplasm and regulate its localization, translation and decay. Some of these factors are known transcriptional regulators that also function in mRNA decay and are hence named synthegradases. Imprinting can be carried out and/or regulated by RNA polymerase II or by promoter cis- and trans-acting elements. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. (C) 2012 Elsevier B.V. All rights reserved.
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