Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1829, Issue 1, Pages 134-140Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2012.08.005
Keywords
Alternative splicing; Transcription; Pol II elongation
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Funding
- Agencia Nacional de Promocion de Ciencia y Tecnologia of Argentina
- University of Buenos Aires
- Howard Hughes Medical Institute
- European Alternative Splicing Network (EURASNET)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
- EU Seventh Framework Programme for Research and Technological Development (FP7) [275632]
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Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. (C) 2012 Elsevier B.V. All rights reserved.
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