Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1829, Issue 6-7, Pages 643-653Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2013.01.004
Keywords
Transcription; mRNA decay; mRNA imprinting; Rpb4/7; Poly(A) binding protein; CCR4-NOT
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Funding
- Gruss Lipper family postdoctoral fellowship
- HHMI fellowship of The Jane Coffin Childs Memorial Fund for Medical Research
- Israel Science Foundation
- US-Israel Binational Foundation
- Israeli Ministry of Health
- [NIHGM57071]
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Recent years have seen a rise in publications demonstrating coupling between transcription and mRNA decay. This coupling most often accompanies cellular processes that involve transitions in gene expression patterns, for example during mitotic division and cellular differentiation and in response to cellular stress. Transcription can affect the mRNA fate by multiple mechanisms. The most novel finding is the process of co-transcriptional imprinting of mRNAs with proteins, which in turn regulate cytoplasmic mRNA stability. Transcription therefore is not only a catalyst of mRNA synthesis but also provides a platform that enables imprinting, which coordinates between transcription and mRNA decay. Here we present an overview of the literature, which provides the evidence of coupling between transcription and decay, review the mechanisms and regulators by which the two processes are coupled, discuss why such coupling is beneficial and present a new model for regulation of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms. (C) 2013 Published by Elsevier B.V.
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