Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1829, Issue 3-4, Pages 405-417Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2012.12.007
Keywords
Chromatin; Transcription; Ribosomal RNA genes; Ribosomal DNA;HMG-box protein; RNA polymerase I; Nucleosome
Categories
Funding
- DFG [SFB960]
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Eukaryotic transcription of ribosomal RNAs (rRNAs) by RNA polymerase I can account for more than half of the total cellular transcripts depending on organism and growth condition. To support this level of expression, eukaryotic rRNA genes are present in multiple copies. Interestingly, these genes co-exist in different chromatin states that may differ significantly in their nucleosome content and generally correlate well with transcriptional activity. Here we review how these chromatin states have been discovered and characterized focusing particularly on their structural protein components. The establishment and maintenance of rRNA gene chromatin states and their impact on rRNA synthesis are discussed. This article is part of a Special Issue entitled: Transcription by Odd Pols. (C) 2012 Elsevier B.V. All rights reserved.
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