Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 6, Pages 3038-3042Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.6.3038-3042.2001
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Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HTV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
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