Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1809, Issue 11-12, Pages 686-693Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2011.05.009
Keywords
MicroRNA; Virus replication; Innate immunity; RNA silencing suppressor; Viral gene expression; Virus-host interaction
Categories
Funding
- NIAID
- Office of the Director, NIH
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MicroRNAs (miRNAs) are small non-coding RNAs that control a multitude of critical processes in mammalian cells. Increasing evidence has emerged that host miRNAs serve in animal cells to restrict viral infections. In turn, many viruses encode RNA silencing suppressors (RSS) which are employed to moderate the potency of the cell's miRNA selection against viral replication. Some viruses also encode viral miRNAs. In this review, we summarize findings from human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) that illustrate examples of host cell miRNAs that target the viruses, of RSS encoded by viruses, and of host cell miRNA profile changes that are seen in infected cells. This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation. Published by Elsevier B.V.
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