Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1809, Issue 1, Pages 34-45Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2010.11.001
Keywords
RNA polymerase II; Gene regulation; Transcription elongation; Polymerase pausing
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Funding
- NIH, National Institute of Environmental Health Sciences [Z01 ES101987]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES101987, Z01ES101987] Funding Source: NIH RePORTER
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Proper regulation of gene expression is essential for the differentiation, development and survival of all cells and organisms. Recent work demonstrates that transcription of many genes, including key developmental and stimulus-responsive genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region. Thus, there is great interest in better understanding the events that follow transcription initiation and the ways in which the efficiency of early elongation can be modulated to impact expression of these highly regulated genes. Here we describe our current understanding of the steps involved in the transition from an unstable initially transcribing complex into a highly stable and processive elongation complex. We also discuss the interplay between factors that affect early transcript elongation and the potential physiological consequences for genes that are regulated through transcriptional pausing. Published by Elsevier B.V.
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