Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1799, Issue 1-2, Pages 28-36Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.11.009
Keywords
High mobility group protein; Post-translational modification; Mass spectrometry
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Funding
- National Institutes of Health [R01 CA116522]
- NATIONAL CANCER INSTITUTE [R01CA116522] Funding Source: NIH RePORTER
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High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. Although the mechanisms through which these modifications are involved in regulating biological processes in different cellular contexts are not fully understood, new insights into these modification codes have emerged from the increasing appreciation of the functions of these proteins. In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions. (C) 2009 Elsevier B.V. All rights reserved.
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