Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1799, Issue 1-2, Pages 131-140Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.11.014
Keywords
HMGB1; Damage associated molecular pattern molecule [DAMP]; Autophagy; Cancer; Angiogenesis; Receptor for advanced glycation endproducts [RAGE]; TLR2; TLR4; CD24; TLR9; Hallmarks of cancer; Field effect; Inflammation
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Funding
- NATIONAL CANCER INSTITUTE [P30CA047904, P01CA101944] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA047904-160008, P01 CA101944-05, P01 CA101944-01A2, P01 CA101944] Funding Source: Medline
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High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those Of Our Colleagues Suggest that HMGB1 is central to cancer (abnormal Wound healing) and many of the findings in normal Wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1. (C) 2009 Elsevier B.V. All rights reserved.
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