Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1799, Issue 1-2, Pages 69-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.11.011
Keywords
HMGN protein; Chromatin; Embryogenesis; Differentiation
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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High mobility group N (HMGN) proteins are the only nuclear proteins known to specifically recognize the generic structure of the 147-bp nucleosome core particle. Both in vitro and in vivo experiments demonstrate that HMGN proteins are involved in epigenetic regulation by modulating chromatin structure and levels of posttranslational modifications of nucleosomal histones. Expression of HMGN proteins is developmentally regulated, and the loss or overexpression of these Proteins can lead to developmental abnormalities. This review will focus on the role and on the possible molecular mechanism whereby HMGN proteins affect cellular differentiation and development. Published by Elsevier B.V.
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