Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1799, Issue 10-12, Pages 717-725Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2010.05.008
Keywords
Histone deacetylase; DNA double strand break; HDAC inhibitor; Mechanism of action; Apoptosis; Suberoylanilide hydroxamic acid
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Funding
- National Institute of Cancer [P30CA08748-44]
- David Koch Foundation
- Jack and Susan Rudin Foundation
- CapCure Foundation
- Experimental Therapeutics at Memorial Sloan-Kettering Cancer Center
- NATIONAL CANCER INSTITUTE [P30CA008748] Funding Source: NIH RePORTER
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There are eleven zinc dependent histone deacetylases (HDAC) in humans which have histones and many nonhistone substrates. The substrates of these enzymes include proteins that have a role in regulation of gene expression, cell proliferation, cell migration, cell death, immune pathways and angiogenesis. Inhibitors of HDACs (HDACi) have been developed which alter the structure and function of these proteins, causing molecular and cellular changes that induce transformed cell death. The HDACi are being developed as anti-cancer drugs and have therapeutic potential for many non-oncologic diseases. (C) 2010 Elsevier B.V. All rights reserved.
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