Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1799, Issue 10-12, Pages 768-774Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2010.08.010
Keywords
Chemical biology; Synthetic biology; Transcription factor mimic; Gene regulation; Cooperative binding; Protein-DNA interaction
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Funding
- NIH
- NCI
- NSF
- March of Dimes
- Greater Milwaukee Foundation
- NATIONAL CANCER INSTITUTE [R01CA133508] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069420] Funding Source: NIH RePORTER
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Transcription factors (TFs) are responsible for decoding and expressing the information stored in the genome, which dictates cellular function. Creating artificial transcription factors (ATFs) that mimic endogenous TFs is a major goal at the interface of biology, chemistry, and molecular medicine. Such molecular tools will be essential for deciphering and manipulating transcriptional networks that lead to particular cellular states. In this minireview, the framework for the design of functional ATFs is presented and current challenges in the successful implementation of ATFs are discussed. (C) 2010 Elsevier B.V. All rights reserved.
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