Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 11, Pages 692-696Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2008.04.008
Keywords
miRNA; microRNA; mode of miRNA-action; metabolism; neural plasticity
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Funding
- Deutsche Forschungsgerneinschaft [DFG FO360/2-1]
- BMBF [01GS0801]
- Munich Center for integrated Protein Science (CIPSM)
- Career Development
- International Human Frontier Science Program Organization
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The importance of microRNAs during development is well recognized, but a number of studies indicate that their function extends to differentiated cells as well. Metabolic control and neural plasticity are dynamic processes in adult organisms and represent good examples where miRNA-mediated regulation affects the function of differentiated cells without changing their fate. We are summarizing the current understanding of how microRNAs contribute to post-transcriptional control of gene expression in these processes and, where possible, highlight in which mode of action - the guardian or the tuning mode - they are employed by the cell. (C) 2008 Elsevier B.V. All rights reserved.
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