Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 11, Pages 655-662Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.06.006
Keywords
miRNA; RISC; Target cleavage; Translational repression
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Funding
- Kentucky Tobacco Research and Development Center (KTRDC)
- USDA-NRI [2006-35301-17115, 2006-35100-17433]
- NSF MCB [0718029, S-00000260]
- NIH [5 R03 Al 068934-02]
- Kentucky Science and Technology Corporation [144-401-08-029]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0718029] Funding Source: National Science Foundation
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MicroRNAs (miRNAs), an endogenous type of small RNAs of similar to 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs. (C) 2008 Elsevier B.V. All rights reserved.
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