Journal
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Volume 23, Issue 2, Pages 79-84Publisher
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/mf.2001.23.2.627931
Keywords
antioxidation; astaxanthin; lipid peroxidation
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Astaxanthin is one of many carotenoids present in marine animals, vegetables and fruits. Since carotenoids are known to have antioxidant properties, we tested to determine if astaxanthin could have protective effects in the CCl4-treated rat liver by activating the antioxidant system. Astaxanthin blocked the increase of glutamate-oxalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GTP) activity and thiobarbituric acid reactive substances (TBARS) in response to carbon tetrachloride (CCl4), while causing an increase in glutathione (GSH) levels and superoxide dismutase (SOD) activities in the CCl4-treated rat liver. These results suggest that astaxanthin protects liver damage induced by CCl4 by inhibiting lipid peroxidation and stimulating the cellular antioxidant system. (C) 2001 Prous Science. All rights reserved.
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