Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 11, Pages 682-691Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.03.001
Keywords
MicroRNA; Skeletal muscle; Satellite cell; Fiber-type; Circadian
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Funding
- NIAMS/NIH [AR053641]
- KAE [AR45617]
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MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myro =muscle+ miR= miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle. (C) 2008 Elsevier B.V. All rights reserved.
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