Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 4, Pages 286-294Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.03.003
Keywords
poly(A) polymerase; poly(U) polymerase; Cid1; RNA regulation; TUTase
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Funding
- Biotechnology and Biological Sciences Research Council [BB/F013531/1] Funding Source: Medline
- Cancer Research UK [A7791] Funding Source: Medline
- Medical Research Council [G0300439] Funding Source: Medline
- BBSRC [BB/F013531/1] Funding Source: UKRI
- MRC [G0300439] Funding Source: UKRI
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The Schizosoccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets. This RNA uridylation pathway appears to be conserved, as Cid 1 orthologs in Arabidopsis thaliana, Caenorhabditis elegans and humans display PUP activity either in vitro or in Xenopus laevis oocytes. Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation. (c) 2008 Elsevier B.V. All rights reserved.
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