Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 4, Pages 266-269Publisher
ELSEVIER
DOI: 10.1016/j.bbagrm.2008.02.001
Keywords
mitochondrial; polyadenylation; poly(A) polymerase; mRNA stability
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Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3' termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria. (c) 2008 Elsevier B.V. All rights reserved.
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