Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1779, Issue 8, Pages 432-437Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2008.07.006
Keywords
miR-124; miR-9; neurogenesis; REST; chromatin remodeling; histone modification; acetylation; methylation; miRNA; ncRNA; bHLH
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Funding
- NIGMS NIH HHS [P01 GM081621] Funding Source: Medline
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The transcriptional programs of neural progenitor cells change dynamically during neurogenesis, a process regulated by both intrinsic and extrinsic factors. Although many of the transcription factors required for neuronal differentiation have long been identified, we are only at the brink of understanding how epigenetic mechanisms influence transcriptional activity and the accessibility of transcription factors to bind consensus cis-elements. Herein, we delineate the chief epigenetic modifications and the machinery responsible for these alterations. Further, we review the epigenetic modifications presently known to participate in the maintenance of the neural progenitor cell state and in the regulation of neuronal differentiation. Published by Elsevier B.V.
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