Journal
ARCHIVES OF TOXICOLOGY
Volume 75, Issue 1, Pages 62-64Publisher
SPRINGER-VERLAG
DOI: 10.1007/s002040000198
Keywords
di(2-ethylhexyl) phthalate; mono(2-ethylhexyl) phthalate; rat; blood
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We measured the background levels of di(2-ethylhexyl) phthalate (DEHP) and its hydrolytic metabolite mono(2-ethylhexyl) phthalate (MEHP) in blood from naive female Sprague-Dawley rats and in de-ionized charcoal-purified water using an analytical procedure that is based on sample treatment with acetonitrile, n-hexane extraction and analysis by gas chromatography. In blood, blank values of 91.3 +/- 34.7 mug DEHP/1 (n=31) and 30.1 +/- 13.1 mug MEHP/1 (n=20) were obtained, and in water, values of 91.6 +/- 44.2 mug DEHP/1 (n = 26) and 26.7 +/- 10.4 mug MEHP/1 (n = 15) were found. Since there is no difference between the background valves obtained from blood of naive rats and water, we conclude that DEHP and MEHP result from contamination during the analytical procedure.
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