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Antigen processing by the proteasome

Journal

NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 3, Pages 179-187

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NATURE PUBLISHING GROUP
DOI: 10.1038/35056572

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The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes - the waste-disposal units of the cell - typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?.

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