Journal
NATURE REVIEWS GENETICS
Volume 2, Issue 3, Pages 207-216Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35056058
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Most eukaryotic chromosomes, akin to messy toolboxes, store jumbles of genes with diverse biological uses. The linkage of a gene to a particular chromosome therefore rarely hints strongly at that gene's function. One striking exception to this pattern of gene distribution is the human Y chromosome. far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex-specific chromosomes.
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