Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1828, Issue 2, Pages 309-316Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2012.10.022
Keywords
Quercetin; Resveratrol; Sodium deoxycholate; Elastic liposome; Experimental design; Nanotechnology
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Funding
- Foundation for Science and Technology Development of the Pernambuco State of Brazil - FACEPE
- Brazilian Council for Research and Technological Development, CNPq [477463]
- FACEPE [APQ0676-4.03/10]
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Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149 nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3 mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat. (C) 2012 Elsevier B.V. All rights reserved.
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