Journal
MOLECULAR CELL
Volume 7, Issue 3, Pages 559-570Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(01)00203-9
Keywords
-
Categories
Funding
- NIDDK NIH HHS [DK31036, DK09825-02, DK34928] Funding Source: Medline
Ask authors/readers for more resources
Insulin signaling is mediated by a complex network of diverging and converging pathways, with alternative proteins and isoforms at almost every step in the process. We show here that insulin activates the transcription of its own gene and that of the 8 cell glucokinase gene (PGK) by different mechanisms. Whereas insulin gene transcription is promoted by signaling through insulin receptor A type (Ex11-), PI3K class la, and p70s6k, insulin stimulates the PGK gene by signaling via insulin receptor B type (Ex11+), PI3K class Ii-like activity, and PKB (c-Akt). Our data provide evidence for selectivity in insulin action via the two isoforms of the insulin receptor, the molecular basis being preferential signaling through different PI3K and protein kinases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available