Journal
MECHANISMS OF DEVELOPMENT
Volume 101, Issue 1-2, Pages 263-265Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00571-2
Keywords
drm; gremlin; BMP; somites; myotome; dermatome; branchial arches; chicken embryo
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The drm gene encodes a cystine knot-containing secreted and cell membrane-associated glycoprotein shown to be an antagonist of BMPs. Drm was recently reported to play a crucial role in limb bud development, by its capacity to bind BMPs. Here, we have studied the expression pattern of drm transcripts during chicken development, by using whole-mount in situ hybridization. We show that, from stage 22HH to stage 26HH, in addition to limb buds, drm is expressed in cephalic neural crest-derived branchial arches I, II and III, in the medio-dorsal lip of the myotome and in the superficial dermatome. (C) 2001 Elsevier science ireland Ltd. All rights reserved.
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