Markers of inflammation and myofibrillar proteins following eccentric exercise in humans

The purpose of this study was to examine the time-course and relationships of technetium-99m (Tc-99m) neutrophils in muscle, interleukin-6 (IL-6), myosin heavy chain fragments (MHC), eccentric torque, and delayed onset muscle soreness (DOMS) following eccentric exercise in humans. Twelve male subjects completed a pre-test DOMS questionnaire, performed a strength test and had 100 ml blood withdrawn for analysis of plasma IL-6 and MHC content. The neutrophils were separated, labelled with (99mT)c, and reinfused into the subjects immediately before the exercise.