Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 114, Issue 1-2, Pages 107-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00459-8
Keywords
apolipoprotein E; microglia; TNFa; IL-6; IL-1
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Funding
- NIA NIH HHS [1RO3AG16507-01] Funding Source: Medline
- NINDS NIH HHS [1RO1NS368087-01A2] Funding Source: Medline
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Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNF alpha, Il-1 beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease. (C) 2001 Elsevier Science B.V. All rights reserved.
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