Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1818, Issue 8, Pages 2076-2081Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2011.09.025
Keywords
Cell based delivery; siRNA, miRNA; Gap junction; Exosomes; Endosomes
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Funding
- NIH [GM RO-1 88180, GM RO-1 88181]
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In vivo delivery of small interfering RNAs (siRNAs) to target cells via the extracellular space has been hampered by dilution effects and immune responses. Gap junction-mediated transfer between cells avoids the extracellular space and its associated limitations. Because of these advantages cell based delivery via gap junctions has emerged as a viable alternative for siRNA or miRNA delivery. Here we discuss the advantages and disadvantages of extracellular delivery and cell to cell delivery via gap junction channels composed of connexins. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics. (C) 2011 Published by Elsevier B.V.
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