Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 3, Pages 304-307Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000456u
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Funding
- NCI NIH HHS [CA53001] Funding Source: Medline
- NIGMS NIH HHS [GM44796] Funding Source: Medline
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Two new cyclodepsipeptides have been isolated from a population of the marine cyanobacterium Lyngbya majuscula collected at Piti Bomb Holes, Guam. They appear to be unique to this particular Guamanian collection and have been named pitipeptolides A (1) and B (2). Their structures have been elucidated by spectroscopic techniques and by characterization of degradation products. Distinctive features include the presence of a 2,2-dimethyl-3 -hydroxy-7-octynoic acid residue in 1 and a 2,2-dimethyl-3-hydroxy- 7-octenoic acid residue in 2, previously shown to be biosynthetic signatures of cyanobacterial metabolites. Pitipeptolides A(1) and B (2) exhibit weak cytotoxicity against LoVo cancer cells, but possess moderate antimycobacterial activity and stimulate elastase activity.
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