Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1808, Issue 2, Pages 580-588Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2010.04.008
Keywords
Kcv; Chlorella virus; Viral ion channel; K+ channel structure function
Categories
Funding
- Deutsche Forschungsgemeinschaft
- European Drug Initiative on Channels and Transporters (EDICT) [201924]
- National Institute of General Medical Sciences [GM32441]
- NIH, National Center for Research Resources [P20-RR1565]
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Some algal viruses contain genes that encode proteins with the hallmarks of K+ channels. One feature of these proteins is that they are less than 100 amino acids in size, which make them truly minimal for a K+ channel protein. That is, they consist of only the pore module present in more complex K+ channels. The combination of miniature size and the functional robustness of the viral K+ channels make them ideal model systems for studying how K+ channels work. Here we summarize recent structure/function correlates from these channels, which provide insight into functional properties such as gating. pharmacology and sorting in cells. (C) 2010 Elsevier B.V. All rights reserved.
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