Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1798, Issue 9, Pages 1735-1738Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2010.06.004
Keywords
Cholesterol; Lipid bilayers; Inverted hexagonal phases; Phospholipid; Sphingomyelin; Extrusion vesicles
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Funding
- Spanish Ministerio de Ciencia e Innovacion [BFU2005-06095]
- Fundacion Areces [06/01]
- Basque Government [IT461-07]
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Cholesterol incorporation into lipid bilayers, in the form of multilamellar vesicles or extruded large unilamellar vesicles, has been quantitated. To this aim, the cholesterol contents of bilayers prepared from phospholipid:cholesterol mixtures 33-75 mol% cholesterol have been measured and compared with the original mixture before lipid hydration. There is a great diversity of cases, but under most conditions the actual cholesterol proportion present in the extruded bilayers is much lower than predicted. A quantitative analysis of the vesicles is thus required before any experimental study is undertaken. (C) 2010 Elsevier B.V. All rights reserved.
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