Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1788, Issue 4, Pages 872-891Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2008.11.005
Keywords
Tight junction; Barrier function; Cancer; Metastasis
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As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are well known as functioning as a control for the paracellular diffusion of ions and certain molecules. It has however. become increasingly apparent that the TJ has a vital role in maintaining cell to cell integrity and that the loss of cohesion of the structure can lead to invasion and thus metastasis of cancer cells. This article will present data showing how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the successful metastasis of a number of different cancer types. (C) 2008 Elsevier B.V. All rights reserved.
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