Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1788, Issue 8, Pages 1687-1692Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2008.09.013
Keywords
Antimicrobial peptide; Cell selectivity; Electrostatic interaction; Hydrophobicity; D-amino acid; Peptpoid
Categories
Funding
- JSPS [20659005]
- Grants-in-Aid for Scientific Research [20659005] Funding Source: KAKEN
Ask authors/readers for more resources
Antimicrobial peptides (AMPs) are promising novel antibiotics, because they exhibit broad antimicrobial spectra and do not easily induce resistance. For clinical applications, it is important to develop potent AMPs with less toxicity against host cells. This review article summarizes the molecular basis for the cell selectivity (bacteria versus host cells) of AMPs and various attempts to control it, including the optimization of physicochemical parameters of peptides, the introduction Of D-, fluorinated, and unusual amino acids into peptides, the constraining of peptide conformations, and the modification of peptides by polymers. Pros and cons of these approaches are discussed. (C) 2008 Elsevier BY. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available