Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1788, Issue 4, Pages 790-796Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2008.12.010
Keywords
Rap1; Junction; Cell-cell contact; Barrier function; E-cadherin; Actin; C3G; PDZ-GEF; Epac1
Categories
Funding
- Dutch Cancer Society
- Netherlands Proteomics Centre
- Centre for Biomedical Genetics
- Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research
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Rap proteins are Ras-like small GTP-binding proteins that amongst others are involved in the control of cell-cell and cell-matrix adhesion. Several Rap guanine nucleotide exchange factors (RapGEFs) function to activate Rap. These multi-domain proteins, which include C3G, Epacs, PDZ-GEFs, RapGRPs and DOCK4, are regulated by various different stimuli and may function at different levels injunction formation. Downstream of Rap, a number of effector proteins have been implicated in junctional control, most notably the adaptor proteins AF6 and KRIT/CCM1. In this review, we will highlight the latest findings on the Rap signaling network in the control of epithelial and endothelial cell-cell junctions. (C) 2009 Elsevier B.V. All rights reserved.
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