Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1788, Issue 1, Pages 149-168Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2008.10.006
Keywords
Computer modeling; Molecular dynamics; Biological membrane; Non-lamellar phase; Self-assembly; Phase transformation; Membrane pore; Vesicle; Lipid flip-flop
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Funding
- National Science and Engineering Research Council (Canada)
- Canadian Institutes of Health Research (CIHR)
- Netherlands Organisation for Scientific Research (NWO)
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In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies. (C) 2008 Elsevier B.V. All rights reserved.
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