Journal
CHEMICAL SOCIETY REVIEWS
Volume 30, Issue 2, Pages 104-112Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b004175k
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Recent advances in on-line interfacing of liquid separation methods with matrix-assisted laser desorption ionisation (MALDI) mass spectrometry are reviewed. A number of concepts for this purpose are described, including pneumatic nebulisation creating an aerosol, use of continuous flow probes, and mechanical introduction with a rotating ball inlet or a vacuum deposition interface. Additionally, a MALDI source operating at ambient pressure has recently been introduced, opening a very simple and reliable way to obtain on-line MALDI measurements. Advantages and limitations of these interfaces are discussed.
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